Resveratrol for Dogs Supplement
Recommended For Dogs Over 10 Pounds
Excellent Value: One bottle is a 4 - 6 month supply for pets under 45 pounds
What is Resveratrol for Dogs?
Resveratrol For Dogs is an antioxidant supplement for dogs, backed by research that can help your dog in so many ways:
- Cardiovascular Health
- Cancer Support and Preventative
- Neuroprotective & Energizing For Senior Dogs
- Supports Cartilage, Disc & Joint Health
- Energizing Supplement for Older Dogs
Resveratrol for Dogs is an exceptional combination of two powerful antioxidants: resveratrol and quercetin. Free radicals (waste products from cellular chemical reactions) may have a damaging affect particularly on the cardiovascular system and neurons in the brain and is also implicated in the aging process. Antioxidants combat free radicals, keeping free radicals in check, helping to reduce the impact of their damage. Quercetin and Resveratrol are two cancer-fighting antioxidants that have shown promising results in research and are blended together to have a more beneficial effect.
Our Resveratrol for Dogs is sourced from Japanese knotweed and contains high concentrations of trans-resveratrol, the active form of the compound most useful to the body. The combination of the quercetin and lecithin together with the resveratrol have a synergistic effect and promote increased nutrient absorption. Research has proven resveratrol to be a very powerful antioxidant which has anti-inflammatory, anti-cancer and neuroprotective properties. While resveratrol is great for dogs of all ages, it is one of the best supplements for older dogs as it supports them through the aging process.
Resveratrol for Dogs is safe for dogs and only a small amount is needed so it is very affordable. Our resveratrol dog capsules are packaged in environmentally-friendly, dark glass bottles. Due to their nonporous and impermeable nature, glass bottles preserve freshness, maintain product integrity and are the premier bottling choice for this product.
- Supports Cardiovascular and Heart Health
Many pets develop heart problems as they age. Common heart disease problems may include heart murmurs, high blood pressure (hypertension), poor valve function or congestive heart failure. Natural supplements can help to strengthen the heart muscle and support cardiovascular health. Research* shows that Resveratrol provides cardioprotective benefits by reducing inflammation in the heart and cardiovascular system and by improving endothelial function. Endothelial cells are responsible for releasing substances that control heart contraction and relaxation as well as enzymes essential for blood clotting and immune function. These properties support heart health and lower the risk of heart diseases.
*Reference: Resveratrol and Clinical Trials: The Crossroad From in Vitro Studies to Human Evidence. Current Pharmaceutical Design. (2013) 19: 6064. Joao Tomé-Carneiro, Mar Larrosa, Antonio González-Sarrías, et al.
The warning signs of heart disease may not appear until the condition has progressed to an advanced state, so being proactive is extremely important. Certain dog breeds are more prone to developing heart conditions These breeds include Cavalier King Charles Spaniels, Dachshunds, Poodles, Doberman Pinscher, Boxer, Schnauzers, and Great Danes. Adding Resveratrol for Dogs can provide cardioprotective support for aging dogs and dogs with heart disease. By strengthening the heart, you may help your dog live a longer and healthier life.
Resveratrol For Dogs contains Japanese knotweed root, an antioxidant with anti-microbial, anti-inflammatory and cardioprotective properties. It can increase circulation, especially to the heart and joints, assisting in treatment for conditions such as Lyme disease in dogs. Lyme disease is characterized by systemic, chronic inflammation. Resveratrol can help to increase blood flow into areas where the Borrelia bugdorferi bacteria can hide making this one of the best supplements for treating Lyme disease in dogs. Researchers* from the Johns Hopkins Bloomberg School of Public Health tested the effectiveness of 14 plant-based extracts in the treatment of Lyme Disease. Japanese knotwood, which is safe for dogs, was one of the top two most effective in killing off the Lyme bacteria.
*Reference: Research Article. Frontiers in Medicine. 21 February 2020. Evaluation of Natural and Botanical Medicines for Activity Against Growing and Non-growing Forms of B. burgdorferi. Jie Feng, Jacob Leone, Sunjya Schweig and Ying Zhang.
- Cancer Support And Preventative
Many veterinarians recommend antioxidants for dogs especially when they are older, have cancer or are a breed with a higher incidence of cancer. Antioxidants are scavengers of free radicals, waste products that arise from cellular chemical reactions in your pet’s body. The damage to cells caused by free radicals may play a role in the development of cancer. Antioxidants fight the oxidative stress and damage, potentially reducing the risk of developing cancer. Animal research studies indicate that resveratrol could inhibit the growth and spread of cancer cells. It is thought to hinder cancer cell growth by changing gene expression and interfering with hormone expression, thereby slowing the replication and spread of the cells.
Resveratrol and quercetin are being researched for how they act on the cancer process including metastasis. Research by Susanne Mertens-Talcott on human leukemia cells reveals that when resveratrol and quercetin are given together they more strongly induce caspase 3 activity which means they are able to induce an apoptosis effect on the cancer cells. Resveratrol acts on the process of carcinogenesis by affecting all three phases: tumor initiation, promotion and progression and suppresses the final steps of carcinogenesis. Another study* on the anticancer effects of resveratrol showed that it may be useful as an adjunct therapy in canine hemangiosarcoma patients.
*Reference: Anticancer Effects of Resveratrol in Canine Hemangiosarcoma Cell Lines. Veterinary and Comparative Oncology. 2018 Jun;16(2):253-261. A Carlson, K S Alderete, M K O Grant, et al.
Certain breeds such as Golden Retrievers, German Shepherds, Poodles, Rottweilers, Labrador Retrievers and Bichon Frises have a higher rate of cancer than most other breeds. Please note however that resveratrol, while helpful for cancer protection and support, will not eradicate cancer.
- Neuroprotective & Energizing For Older Dogs
Many pet owners seek out supplements for older dogs to bring back the “puppy in their pet”. Resveratrol for Dogs helps to support your dog through the aging process by neutralizing damaging free radicals and protecting the brain and nervous system. All antioxidants fight free radicals, but unlike most antioxidants for dogs, resveratrol is able to cross the blood-brain barrier, which allows it to protect against inflammation in the brain. Research* shows that it can help to reduce the plaque buildup associated with canine cognitive dysfunction or doggie dementia.
*Reference: Dietary Supplementation With Resveratrol Reduces Plaque Pathology in a Transgenic Model of Alzheimer's Disease. Neurochemistry International. Volume 54, Issue 2, February 2009, Pages 111-118. Saravanan S.Karuppagoundera, John T.Pinto, Hui Xu, et al.
The damage from free radicals in the cardiovascular and neurological systems can have a huge impact on our pet’s overall health as they age. Mitochondria, the cellular energy producers, of the brain neurons are especially affected and this is apparent when we see cognitive decline and reduced activity and energy levels. This decreased function of the brain can affect memory and mood in older dogs.
How can a plant polyphenol protect the brain? The ability of Resveratrol for Dogs to cross the blood-brain barrier, allows it to reduce the oxidative damage to neurons, thereby improving cellular energy production. More energy can mean better brain function, improved alertness and increased energy for walks and playing.
There are several exciting research studies showing the renoprotective effects of Resveratrol supplementation. The antioxidant supplement helps to reduce fibrosis, prevent diabetic nephropathy, and reduce oxidative stress and inflammation in the kidneys.* Resveratrol helps to preserve kidney structure and function in pets with compromised kidney function.
Resveratrol may also be useful in preventing diabetic kidney damage. Diabetic pets accumulate excess sugar in the blood and the kidneys can become overworked while filtering out the sugar. Diabetes is one of the leading causes of kidney disease and decreased kidney function. Scientific research shows the important role of oxidative stress in diabetic kidney disease and indicates the antioxidative properties may be responsible for the renoprotective action of resveratrol.**
*Reference: Renal Protective Effects of Resveratrol. Oxidative Medicine and Cellular Longevity. Vol. 2013, Article ID 568093, 7 pages, 2013. Munehiro Kitada, Daisuke Koya.
**Reference: Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats. Pharmacology. Epub 2005 Nov 11. Sameer Sharma, Muragundla Anjaneyulu, S K Kulkarni, Kanwaljit Chopra.
- Supports Cartilage, Disc & Joint Health
Arthritis and joint pain could be causing your senior dog to slow down. Inflammation and swelling stimulates healing in a healthy body, but as your dog ages and the joints wear and degenerate, the inflammation becomes chronic and causes pain. Resveratrol is a holistic dog antioxidant supplement with anti-inflammatory properties. This natural supplement may help reduce the need for non-steroidal anti-inflammatory drugs and relieve joint pain.
Resveratrol research* suggests that this plant-based supplement can reduce inflammation and help protect cartilage from breaking down. Cartilage is the connective tissue that helps joints move without grinding or friction. Resveratrol may help to relieve joint pain by preventing the deterioration of cartilage.
*Reference: Effects of Resveratrol in Inflammatory Arthritis. Inflammation. 30, 1–6 (2007). Elmali, N., Baysal, O., Harma, A. et al.
There is exciting research* that shows sirtuins, proteins that regulate cellular health and protect the body from oxidative stress, may play a role in preventing cartilage deterioration. Sirtuin 1 (SIRT-1) can inhibit the progression of arthritis with its anti-inflammatory properties and can help to preserve bone homeostasis. Resveratrol is the natural activator of SIRT-1. Adding resveratrol supplements can help to increase the positive effects of natural sirtuins.
*Reference: The role of sirtuin 1 and its activator, resveratrol in osteoarthritis. Bioscience Reports. (2019) 39 (5): BSR20190189. Zhenhan Deng; Yusheng Li; Haifeng Liu; et al.
Intervertebral disc disease (IVDD) in dogs is a condition where the cushioning “shock absorber” discs between the vertebrae in the spinal column either rupture or degenerate. This can cause pain, loss of limb function (partial or complete) and paralysis. A ruptured or “slipped” disc tends to happen in younger, active dogs. Degenerative IVDD is a slow, progressive condition that can lead to spinal cord compression accompanied by pain and a loss of mobility usually older, large breed dogs. Studies* have shown that resveratrol shows considerable potential for the repair and regeneration of intervertebral discs.
*Reference: The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc. Spine. November 15, 2008 - Volume 33 - Issue 24 - p 2586-2595. Li, Xin, MD, PhD; Phillips, Frank M., MD; An, Howard S., MD; et al.
Resveratrol can be combined with our other joint support supplements for comprehensive arthritis and joint support.
ArthroSoothe for Pets contains resveratrol in combination with 14 other ingredients scientifically proven to promote joint repair, increase mobility and reduce joint degeneration.
Ultra-Flex Collagen is a natural whole-food supplement that builds cartilage, joint and connective tissue. Around 80% of your pet’s muscles, tendons, and ligaments are made up of collagen and it is crucial in keeping these connective tissues flexible.
Resveratrol for Dogs Ingredients (1 capsule):
Trans-Resveratrol 200 mg (from Japanese Knotweed) (Polygonum cuspidatum)(root)
Quercetin 200 mg
Other Ingredients: Cellulose (capsule), sunflower lecithin, microcrystalline cellulose, vegetable stearate, silicon dioxide
Made in the USA. No dairy, gluten, or soy. Non GMO.
Resveratrol for Dogs is made using the highest quality ingredients and is manufactured under strict GMP (Good Manufacturing Practices) standards. These rigorous standards are applied throughout the production process, from the sourcing of the raw materials and the strict control of the production environment to the analytical tests essential to ensuring quality, safety and reliability. The resulting encapsulated combination of resveratrol from polygonum, quercetin dihydrate, and lecithin proved to be the most effective, economical, and stable formulation. In addition, before and after production, each lot is tested for trans-resveratrol content.