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Special SAMe For Dogs

sam e for dogs


Backed By Scientific Research

Used Successfully In Veterinary Hospitals Since 2005

Powerful Antioxidant Formula That Provides These Scientifically Proven Benefits:

  • Supports Liver Function - Helps Reduce Elevated Liver Enzymes
  • Arthritis - Improves Mobility And Reduces Arthritis Pain
  • Helps Maintain Liver Function In Pets Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
  • Brain Support - Excellent For Dogs With Dementia

Use Coupon Code "sam" At Checkout

Our Price: $43.95

Description Benefits Testimonials

SAMe Liver Supplement for Dogs

Special SAMe (S-Adenosyl methionine) Supplement For Dogs

200 mg 30 Vegetarian capsules - Formulated For Pets Over 13 Pounds

What Is Special SAMe?

Special SAMe (S-adenosyl-L-methionine) for dogs is a powerful antioxidant scientifically proven and widely prescribed for osteoarthritis, liver support and detoxification, and cognitive disorders. It is especially important to use if your dog is taking pain or anti-inflammatory medications, which can be harmful to your pet's liver.

Our Special SAMe is manufactured with exceptional care and is third-party tested to guarantee potency and purity. SAM-e for dogs is extremely sensitive to degradation from air and moisture, which is why the quality of the manufacturing process is so important. Special SAMe capsules are packaged in environmentally-friendly, dark glass bottles. Due to their nonporous and impermeable nature, glass bottles preserve freshness, maintain product integrity and are the premier bottling choice for this product. These capsules provide 200 mg of SAM-e for dogs along with vitamins B6, B12 and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAM-e. This improves the bioavailability, absorption and effectiveness of the product.

Special SAMe for Dogs Can Benefit the Following:

  • Dogs with elevated liver enzymes, liver disease or liver shunts
  • Dogs with hip dysplasia, elbow dysplasia and arthritic conditions
  • Senior pets that are depressed, slowing down or having coordination issues
  • Senior dogs with mental confusion or dementia
  • Dogs with cancer (especially liver cancer)

Powerful Antioxidant Formula Provides Scientifically Proven Benefits

Special SAMe is the single most important supplement to use if your dog has elevated liver enzymes. It’s recommended by veterinarians, and it’s scientifically proven to reduce elevated liver enzymes*, relieve arthritic pain and support brain health.

Special SAM-e is recommended by veterinarians for arthritis and joint pain treatment because it promotes cellular growth repair and helps to protect the cartilage in the joints. We have seen that when taking Special SAMe, dogs with hip dysplasia and chronic joint pain experienced improvements when other supplements didn't help.
*Reference: Research study: The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile. J Vet Intern Med. May-Jun 2005;19(3):303-14.

  • Protection and Detoxification of the Liver

    The liver is the body’s main organ of detoxification. Special SAMe helps support liver health by supplementing metabolic activity, helping maintain glutathione levels* (which is known to be protective and detoxifying for the liver) and supporting cell regeneration. SAM-e is widely recommended by veterinarians for dogs because it is safe and effective, with the only reported side effect being rare instances of stomach upset.

    *Reference: Research study: Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects...Am J Vet Res.. 2005;66:330-341.

  • Liver Support For Pets Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as Rimadyl, Deramax, or Meloxicam are prescribed by veterinarians for pain. These medications can provide temporary relief but should be used sparingly, as they can affect your dog's liver function. Many NSAIDs are processed through the liver, so using Special SAMe is especially important. Special SAMe (S-adenosylmethionine for Dogs) is scientifically proven to support liver detoxification and can help with arthritis and mobility. It is an excellent companion product to give your dog if you are using an NSAID drug.

  • Arthritis and Joint Pain Management

    Arthritis is a chronic degenerative disease that can cause joint pain, which limits your pet's mobility. The pain may cause your dog to have stiffness, difficulty walking up stairs and discomfort getting up and down. Special SAMe can reduce pain and inflammation associated with arthritis by increasing proteoglycan production, a component important for lubricating your dog's joints. In some studies, SAM-e for dogs was shown to be as effective as nonsteroidal anti-inflammatory drugs, with lower toxicity risk. There is much research supporting the use of SAM-e for pain management in dogs.

  • SAM-e for Canine Cognitive Dysfunction

    As dogs age, their natural levels of S-adenosyl-L-methionine begin to decline. SAMe is essential for the synthesis of choline and melatonin. Choline supports brain and nerve function, and melatonin regulates sleep. SAMe is also believed to increase the turnover of serotonin and increase levels of dopamine. SAMe can help to regulate the sleep-wake cycle and may help pets (especially seniors) with mental confusion and dementia. Over the years, many clients have reported that their senior dogs have more energy and an increased bounce in their step after being given Special SAMe. Scientific studies* have shown that SAMe is a safe and effective oral supplement for improving signs of mental decline in dogs older than eight years.
    *Reference: Research study: Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs Veterinary Therapeutics. 2008 Summer;9(2):69-82.


“Today is the five year anniversary since I adopted Bella as a 12 year old senior from Precious Paws Asians and Small Dog Rescue, for whom I regularly foster and rescue. Four of my six dogs, including Bella and Lilibeth are from the Rescue.

Bella’s health has been outstanding since I adopted her. In May 2019, out of nowhere, Bella took an extreme turn for the worse. The always smiling friendly personality no longer existed. I took her to my vet who diagnosed her with Canine Dementia. Her liver numbers were through the roof. She went blind in her other eye. This little resilient dog that always loved walks, no longer would go on walks. She had to be carried outside and carried inside. She was still eating, but she was existing, not really living. It absolutely entered the equation that a difficult decision might have to be made.

My view has always been that as long as there is life, there is hope. I started researching treatments for Canine Dementia. I came across Ask Ariel, first Brain Booster, then Special SAMe, which seemed like the absolutely perfect remedy for Bella, as not only did it address the Dementia and arthritis, but also provided support for Bella’s elevated liver numbers. So after a few weeks of zombie Bella, I started her on Special SAMe. Within a short period of time, Bella started to come out of her funk. The first day she walked again on the leash was so special. The results have been nothing short of miraculous.

As a lawyer, our cases often hinge on “causation”, meaning what caused the damages that are the subject of the case. Looking at Bella’s recovery, I can state without reservation, that the cause of her miraculous turnaround, was when I started her on Special SAMe. That was the precise turning point.

Since that time Bella has shown no signs of relapse. I also recently rescued Lilibeth a Senior Blind Shih Tzu, who has likewise shown remarkable improvement since I started her on Special SAMe. I swear by Special SAMe without reservation. My vet likewise verified that the product works. No dog owner whose dog develops Canine Dementia should ever consider giving up on their dog without first trying Special SAMe. I hope Bella’s story helps." -
Michael S. Kasanoff, Esq., New Jersey


“Our 14 year old dog Davy has to take liver support and we were using the prescription medication Denamarin from our veterinarian but he was getting a very upset tummy and having diarrhea. He is doing much better using the Special SAMe. He is not having the tummy noises and is acting a lot better." - Elaine, CA


Amount Per 200-mg Capsule:

(Please note that the 200 mg capsule size is appropriate for pets over 13 lbs)

Vitamin B6 (as pyridoxal 5’-phosphate) 5mg
Folate (Quatrefolic) (as [6S]-5-methyltetrahydrofolate, glucosamine salt) 100mcg
Vitamin B12 (as methylcobalamin) 50mcg
SAMe (as S-adenosyl-L-methionine disulfate P-toluenesulfonate) 200mg

Other Ingredients: Microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide

Product FAQs
Special SAMe Frequently Asked Questions (FAQs)

What is SAM-e for dogs?

S-adenosylmethionine (SAM-e) is a compound that is made naturally in the body. It is the bioactive form of the amino acid methionine. SAM-e helps to supplement metabolic activity and it supports cell regeneration. Most SAM-e is produced and consumed in the liver. If your dog has elevated liver enzymes or is showing signs of aging, such as osteoarthritis or canine cognitive dysfunction, Ask Ariel's Special SAMe can help. It provides excellent support for dogs with elevated liver enzymes, liver disease or shunts, cancer, hip or elbow dysplasia, arthritis and senior pets showing cognitive decline.

Can you give SAM-e to dogs?

SAM-e occurs naturally in both humans and dogs. When the liver is no longer producing enough, it can be beneficial to add supplements. Supplemental SAM-e is used for the same purposes in dogs as it is in people. SAM-e for dogs helps with liver detox, osteoarthritis joint pain and canine cognitive disorders. Ask Ariel's Special SAMe is the finest human grade supplement and is recommended by veterinarians nationwide.

What is the best SAM-e supplement for dogs?

Ask Ariel's Special SAMe is the best S-Adenosylmethionine for dogs. It is blended with vitamins to improve bioavailability, absorption and effectiveness. Our SAM-e is packaged in glass bottles to prevent plastic toxins from leaching into the supplement. It is third party tested to guarantee potency and purity.

Can a dog recover from liver damage?

Your dog's liver is important in the digestion and conversion of nutrients, removing toxic substances from the blood, and the storage of vitamins and minerals. When your dog has elevated liver values and damage, the liver is not functioning at an optimum level. The good news is that the liver is the only organ that can regenerate. Ask Ariel's Special SAMe is a powerful antioxidant that is backed by scientific research and is shown to detoxify the liver and promote cell regeneration.