Home > Pet Supplements >

Special SAMe For Dogs
sam e for dogs


Backed By Scientific Research

Used Successfully in Veterinary Hospitals Since 2005

Powerful antioxidant formula that provides these scientifically proven benefits:

  • Supports Liver Function - Helps Reduce Elevated Liver Enzymes
  • Arthritis - Improves Mobility and Reduces Arthritis Pain
  • Brain Support - Excellent For Dogs With Dementia

SALE: Save $5 Per Bottle

+ FREE SHIPPING When You Buy 2
Use Coupon Code At Checkout: sam

Our Price: $42.95
Sale Price: $37.95
Savings: $5.00

Description Benefits Testimonials
Special SAMe (S-Adenosyl methionine) Supplement For Dogs

200 mg 30 Vegetarian capsules - Formulated For Pets Over 13 Pounds

What is Special SAMe?

Special SAMe (S-Adenosyl methionine) for dogs is a powerful antioxidant scientifically proven and widely prescribed for the treatment of osteoarthritis, liver support and detoxification as well as cognitive disorders. It is especially important to use if your dog is taking pain or anti-inflammatory medications which can be harmful to your pet's liver.

Our Special SAMe is manufactured with exceptional care and is third-party tested to guarantee potency and purity. SAM-e for dogs is extremely sensitive to degradation from air and moisture, which is why the quality of the manufacturing process is so important. For example, our glass bottle prevents leakage of toxins from plastic into the SAM e. These capsules provide 200 mg of SAM-e for dogs along with vitamins B6, B12, and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAM-e. This improves the bioavailabilty, absorption and effectiveness of the product.

Powerful Antioxidant Formula Provides Scientifically Proven Benefits

Special SAMe is the single most important supplement to use if your dog has elevated liver enzymes. Recommended by veterinarians, scientifically proven to reduce elevated liver enzymes, relieve arthritic pain and support brain health.

Special SAM-e is recommended by veterinarians for arthritis and joint pain treatment because it promotes cellular growth repair and helps to protect the cartilage in the joints. We have seen dogs with hip dysplasia and chronic joint pain improve with Special SAMe when other supplements didn't help.

  • Protection and Detoxification for the Liver

    The liver is the body’s main organ of detoxification. Special SAMe helps support liver health by supplementing the metabolic activity, helping maintain glutathione levels (which is known to be protective and detoxifying for the liver) and supports cell regeneration. SAM-e is widely recommended by veterinarians for dogs because it is safe and effective with the only reported side effect being rare instances of stomach upset.

  • Arthritis and Joint Pain Management

    Arthritis is a chronic degenerative disease that can cause joint pain which limits your pet's mobility. The pain may cause your dog to have stiffness, difficulty walking up stairs and discomfort getting up and down. Special SAMe can reduce pain and inflammation associated with arthritis by increasing proteoglycan production, a component important for lubricating your dog's joints. In some studies, SAM-e for dogs was shown to be as effective as non-steroidal anti-inflammatory drugs with lower toxicity risk. There is much research supporting the use of SAM-e for pain management in dogs.

  • Helps Cognitive Disorders

    SAMe is believed to increase the turnover of serotonin and increase levels of dopamine which may help pets (especially seniors) with mental confusion and dementia. Over the years, many clients report that their senior dogs have more energy and an increased bounce in their step after Special SAMe.

Special SAMe Can Benefit:

  • Dogs with elevated liver enzymes.
  • Dogs with liver disease or liver shunts.
  • Dogs with cancer (especially liver cancer).
  • Dogs with hip dysplasia, elbow dysplasia and arthritic conditions.
  • Senior pets that are depressed, slowing down or having coordination issues.
  • Scottish terriers with "Scotty cramps", a condition brought on by low serotonin.


“Our 14 year old dog Davy has to take liver support and we were using the prescription medication Denamarin from our veterinarian but he was getting a very upset tummy and having diarrhea. He is doing much better using the Special SAMe. He is not having the tummy noises and is acting a lot better." - Elaine, CA


Amount Per 200 mg Capsule:

(Please note that the 200 mg capsule size is appropriate for pets over 13 lbs)

Vitamin B-6 (as Pyridoxal-5 Phosphate) 5mg
Folate (Quatrefolic)(as [6s]-5 Methyltetrahydrofolate, glucosamine salt) 100mcg
Vitamin B-12 (as Methylcabalamin) 50mcg
SAMe (as S-Adenosyl-L-Methionine Disulfate P-Toluensulfate) 200mg

Other Ingredients: Microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide

Product FAQs
Special SAMe Frequently Asked Questions (FAQs)

What is SAM-e for dogs?

S-adenosylmethionine (SAM-e) is a compound that is made naturally in the body. It is the bioactive form of the amino acid methionine. SAM-e helps to supplement metabolic activity and it supports cell regeneration. Most SAM-e is produced and consumed in the liver. If your dog has elevated liver enzymes or is showing signs of aging, such as osteoarthritis or canine cognitive dysfunction, Ask Ariel's Special SAMe can help. It provides excellent support for dogs with elevated liver enzymes, liver disease or shunts, cancer, hip or elbow dysplasia, arthritis and senior pets showing cognitive decline.

Can you give SAM-e to dogs?

SAM-e occurs naturally in both humans and dogs. When the liver is no longer producing enough, it can be beneficial to add supplements. Supplemental SAM-e is used for the same purposes in dogs as it is in people. SAM-e for dogs helps with liver detox, osteoarthritis joint pain and canine cognitive disorders. Ask Ariel's Special SAMe is the finest human grade supplement and is recommended by veterinarians nationwide.

What is the best SAM-e supplement for dogs?

Ask Ariel's Special SAMe is the best S-Adenosylmethionine for dogs. It is blended with vitamins to improve bioavailability, absorption and effectiveness. Our SAM-e is packaged in glass bottles to prevent plastic toxins from leaching into the supplement. It is third party tested to guarantee potency and purity.

Can a dog recover from liver damage?

Your dog's liver is important in the digestion and conversion of nutrients, removing toxic substances from the blood, and the storage of vitamins and minerals. When your dog has elevated liver values and damage, the liver is not functioning at an optimum level. The good news is that the liver is the only organ that can regenerate. Ask Ariel's Special SAMe is a powerful antioxidant that is backed by scientific research and is shown to detoxify the liver and promote cell regeneration.