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Special SAMe For Dogs

sam e for dogs


SAMe Antioxidant Supplement For Dogs (Over 13 lbs):

  • Supports Liver Function - Helps Reduce Elevated Liver Enzymes
  • Helps Maintain Liver Function In Pets Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
  • Brain Support - May Help Dogs With Dementia
  • Special Encapsulation Process For Optimal Absorption

Use Coupon Code sam At Checkout

Our Price: $44.95


Description Benefits Testimonials

SAMe Liver Supplement for Dogs

Special SAMe (S-Adenosyl methionine) Supplement For Dogs

200 mg 30 Vegetarian Capsules For Dogs Over 13 Pounds
(For cats and small dogs, please contact your veterinarian for an alternative SAMe product.)

Note: Special SAMe contains all natural ingredients without preservatives. This product is best-suited for large dogs. Smaller dogs (over 13 pounds) can still use Special SAMe, but please be advised that the preservative-free ingredients will naturally oxidize. Some capsules may harden and be unusable after a few months.

What Is Special SAMe?

SAMe (S-adenosyl-L-methionine) for dogs is a powerful antioxidant scientifically proven and widely prescribed for osteoarthritis, liver support and detoxification, and cognitive disorders. It is especially important to use if your dog is taking pain or anti-inflammatory medications, which can negatively affect your dog's liver function.

Our Special SAMe is manufactured with exceptional care and is third-party tested to guarantee potency and purity. SAM-e for dogs is extremely sensitive to degradation from air and moisture, which is why the quality of the manufacturing process is so important. Special SAMe capsules are packaged in environmentally-friendly, dark glass bottles. Due to their nonporous and impermeable nature, glass bottles preserve freshness and may help protect nutrient viability. These capsules provide 200 mg of SAM-e along with vitamins B6, B12 and folate which are nutrient cofactors required for the efficient function of SAMe.

Special SAMe for Dogs May Be Beneficial For:

  • Dogs with elevated liver enzymes, liver disease or liver shunts
  • Dogs with hip dysplasia, elbow dysplasia and arthritic conditions
  • Senior pets that are depressed, slowing down or having coordination issues
  • Senior dogs with mental confusion or dementia
  • Dogs with cancer (especially liver cancer)

Antioxidant Supplement For Dogs

Special SAMe is an important supplement to use if your dog has elevated liver enzymes. SAMe is commonly recommended by veterinarians, and has been proven to reduce elevated liver enzymes*, relieve arthritic pain and support brain health.

Special SAM-e is a helpful arthritis and joint pain treatment because it promotes cellular growth repair and helps to protect the cartilage in the joints. It can be used along with other joint support supplements like ArthroSoothe and Ultra-Flex Collagen.
*Reference: Research study: The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile. J Vet Intern Med. May-Jun 2005;19(3):303-14.

  • Protection and Detoxification of the Liver

    The liver is the body’s main organ of detoxification. Special SAMe helps support liver health by supplementing metabolic activity, helping maintain glutathione levels* (which is known to be protective and detoxifying for the liver) and supporting cell regeneration. SAM-e is widely recommended by veterinarians for dogs because it is safe and effective, with the only reported side effect being rare instances of stomach upset.

  • Liver Support For Pets Using Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are prescribed by veterinarians for pain. These medications can provide pain relief but should be used sparingly, as they can affect your dog's liver function. Many NSAIDs are processed through the liver, so using Special SAMe can be helpful. SAMe (S-adenosylmethionine for Dogs) is scientifically proven to support liver detoxification and may help your dog with arthritis and mobility. It is an excellent companion product to give your dog if you are using an NSAID drug.

  • Arthritis and Joint Pain Management

    Arthritis is a chronic degenerative disease that can cause joint pain, which limits your pet's mobility. The pain may cause your dog to have stiffness, difficulty walking upstairs and discomfort getting up and down. Special SAMe can reduce pain and inflammation associated with arthritis by increasing proteoglycan production, a component important for lubricating your dog's joints. In some human studies, SAM-e was shown to be as effective as nonsteroidal anti-inflammatory drugs, with lower toxicity risk.

  • SAM-e for Canine Cognitive Dysfunction

    As dogs age, their natural levels of S-adenosyl-L-methionine begin to decline. SAMe is essential for the synthesis of choline and melatonin. Choline supports brain and nerve function, and melatonin regulates sleep. SAMe is also believed to increase the turnover of serotonin and increase levels of dopamine. SAMe can help to regulate the sleep-wake cycle and may help pets (especially seniors) with mental confusion and dementia. Over the years, many clients have reported that their senior dogs have more energy and an increased bounce in their step after being given Special SAMe. Scientific studies* have shown that SAMe is a safe and effective oral supplement for improving signs of mental decline in dogs older than eight years.
    *Reference: Research study: Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs Veterinary Therapeutics. 2008 Summer;9(2):69-82.


"Today is the five year anniversary since I adopted Bella as a 12 year old senior from Precious Paws Asians and Small Dog Rescue, for whom I regularly foster and rescue. Four of my six dogs, including Bella and Lilibeth are from the Rescue.

Bella’s health has been outstanding since I adopted her. In May 2019, out of nowhere, Bella took an extreme turn for the worse. The always smiling friendly personality no longer existed. I took her to my vet who diagnosed her with Canine Dementia. Her liver numbers were through the roof. She went blind in her other eye. This little resilient dog that always loved walks, no longer would go on walks. She had to be carried outside and carried inside. She was still eating, but she was existing, not really living. It absolutely entered the equation that a difficult decision might have to be made.

My view has always been that as long as there is life, there is hope. I started researching treatments for Canine Dementia. I came across Ask Ariel, first Brain Booster, then Special SAMe, which seemed like the absolutely perfect remedy for Bella, as not only did it address the Dementia and arthritis, but also provided support for Bella’s elevated liver numbers. So after a few weeks of zombie Bella, I started her on Special SAMe. Within a short period of time, Bella started to come out of her funk. The first day she walked again on the leash was so special. The results have been nothing short of miraculous.

As a lawyer, our cases often hinge on “causation”, meaning what caused the damages that are the subject of the case. Looking at Bella’s recovery, I can state without reservation, that the cause of her miraculous turnaround, was when I started her on Special SAMe. That was the precise turning point.

Since that time Bella has shown no signs of relapse. I also recently rescued Lilibeth a Senior Blind Shih Tzu, who has likewise shown remarkable improvement since I started her on Special SAMe. I swear by Special SAMe without reservation. My vet likewise verified that the product works. No dog owner whose dog develops Canine Dementia should ever consider giving up on their dog without first trying Special SAMe. I hope Bella’s story helps." - Michael S. Kasanoff, Esq., New Jersey


"Our 14 year old dog Davy has to take liver support and we were using a prescription medication but he was getting a very upset tummy and having diarrhea. He is doing much better using the Special SAMe. He is not having the tummy noises and is acting a lot better." - Elaine, California



Disclaimer: Testimonials are direct statements from our clients and have not been altered by AskAriel.com. Clients are not paid for their statements.

Product FAQs
Special SAMe Frequently Asked Questions (FAQs)

What is SAM-e for dogs?

S-adenosylmethionine (SAM-e) is a compound that is made naturally in the body. It is the bioactive form of the amino acid methionine. SAM-e helps to supplement metabolic activity and it supports cell regeneration. Most SAM-e is produced and consumed in the liver. SAMe can be beneficial for dogs with elevated liver enzymes, liver disease or shunts, hip or elbow dysplasia, arthritis and senior pets showing cognitive decline.

Can you give SAM-e to dogs?

SAM-e can be safely administered to dogs, under the supervision of a veterinarian. Please work with your veterinarian to determine optimal dosage for your dog and to oversee your dog's progress on the supplement. Not all SAMe supplements are manufactured in the same way and some SAM-e products for dogs may not contain the ingredients stated or at the potency stated. Be sure to look for a SAMe-e supplement for dogs that has been third-party tested for purity and potency. SAM-e may be beneficial for dogs with liver disease, osteoarthritis joint pain and canine cognitive disorders.

Can a dog recover from liver damage?

Your dog's liver is important in the digestion and conversion of nutrients, removing toxic substances from the blood, and the storage of vitamins and minerals. When your dog has elevated liver values and damage, the liver is not functioning at an optimum level. Liver support supplements for dogs that contain ingredients such as SAMe, milk thistle, dandelion and artichoke may help detoxify the liver and promote cell regeneration.